This entry was posted on November 27, 2009 at 12:03 pm and is filed under 882. You can follow any responses to this entry through the RSS 2.0 feed.
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Long and short of it is, I believe having 2 (maybe 3) files will in the long run be a better, faster loading profile, if a dynamic loader like LABjs is used, than if you shove everything into one file and force it to load completely serially, byte-by-byte.
But, again, even if you still insist that one file is the best for your site, using a loader like LABjs will still help it load in parallel to the rest of the page’s resources (CSS, images), which will improve your site’s page load profile.